NFL Week 3 picks, schedule, odds, injuries, stats, fantasy tips

The Week 3 NFL schedule for the 2022 season is stacked with great matchups, and we have you covered with what you need to know heading into the weekend.

Our NFL Nation reporters bring us the biggest keys to every game and a bold prediction for each matchup.

Additionally, ESPN Stats & Information provides a big stat to know and a betting nugget for each contest, and our Football Power Index (FPI) goes inside the numbers with a matchup rating (on a scale of 1 to 100) and a game projection.

ESPN researcher Kyle Soppe hands out helpful fantasy football intel, as well. Finally, Seth Walder and Eric Moody give us final score picks for every game.

Everything you want to know is here in one spot to help you get ready for a loaded weekend of NFL football.

Let's get into the full Week 3 slate, including a faceoff between two top AFC offenses in Buffalo-Miami, Tom Brady vs. Aaron Rodgers for perhaps the last time, Carson Wentz playing his old team and Patrick Mahomes and Matt Ryan doing battle in Indy.

It all culminates with a Monday Night Football matchup between the Cowboys and the Giants on ESPN.

1) Chiefs (2-0) at Colts (0-1-1) 1 p.m. ET | CBS | Spread: KC -5.5 (50.5) Bold prediction: Colts quarterback Matt Ryan will throw as many touchdown passes as Chiefs signal-caller Patrick Mahomes. The Colts have been a difficult puzzle for Mahomes. In two career games against Indianapolis (including playoffs), Mahomes has one TD pass, eight sacks and a QBR of 56.3. -- Adam Teicher

2) Bills (2-0) at Dolphins (2-0) 1 p.m. ET | CBS | Spread: BUF -5.5 (52) Bold prediction: Allen will throw for at least 325 yards and five touchdown passes, continuing his impressive streak of success against the Dolphins (19 passing touchdowns, four rushing touchdowns and three turnovers in his past seven games vs. Miami). 

2) Bills (2-0) at Dolphins (2-0) 1 p.m. ET | CBS | Spread: BUF -5.5 (52) The Dolphins' defense has struggled this season against the pass, giving up a league-high 9.0 yards per passing attempt and a 71.2% completion percentage (28th). Allen leads the NFL in Total QBR (87.1) and should have no problem taking advantage. -- Alaina Getzenberg

3) Raiders (0-2) at Titans (0-2) 1 p.m. ET | Fox | Spread: LV -2.5 (45.5) Bold prediction: Las Vegas edge rusher Chandler Jones will have a three-sack game. He has yet to record a sack for the Raiders after signing a three-year, $52.5 million contract, but he returns to the scene of his five-sack performance in last season's opener. 

3) Raiders (0-2) at Titans (0-2) 1 p.m. ET | Fox | Spread: LV -2.5 (45.5) The guy who should block Jones, Taylor Lewan, suffered a knee injury and might not play. Time for Jones to eat again. -- Paul Gutierrez

4) Ravens (1-1) at Patriots (1-1) 1 p.m. ET | Fox | Spread: BAL -3 (43.5) Bold prediction: The Ravens will rebound and hold the Patriots under 10 points after last week's fourth-quarter collapse. Under coach John Harbaugh, Baltimore has shown perseverance, giving up an average of 19.5 points the week after allowing 40 or more points.

4) Ravens (1-1) at Patriots (1-1) 1 p.m. ET | Fox | Spread: BAL -3 (43.5) New England quarterback Mac Jones has eclipsed 20 points in three of his past eight starts (including playoffs), and the Patriots' 24 points are their fewest through two games since 2001 (20). -- Jamison Hensley

5) Bengals (0-2) at Jets (1-1) 1 p.m. ET | CBS | Spread: CIN -6 (45) Bold prediction: The Bengals will give up 300 passing yards -- in a win. The Jets lead the league in designed pass plays and are 30th in touchdowns allowed per drive, while Flacco has 103 pass attempts through two games (second most by any player since the 1970 merger). 

5) Bengals (0-2) at Jets (1-1) 1 p.m. ET | CBS | Spread: CIN -6 (45) This could be the high-scoring affair that helps the Bengals' offense find its rhythm after a lackluster start to the season. -- Ben Baby

6) Eagles (2-0) at Commanders (1-1) 1 p.m. ET | Fox | Spread: PHI -6.5 (47) Bold prediction: Philadelphia quarterback Jalen Hurts will rush for 100-plus yards. The Commanders are last in the NFL in yards allowed per rush at 7.5. (The Eagles' defense is second worst, by the way, at 6.2.) 

6) Eagles (2-0) at Commanders (1-1) 1 p.m. ET | Fox | Spread: PHI -6.5 (47) That's not the kind of vulnerability you want when facing an Eagles team that led the league in rushing a year ago and ranks second in that category (379 yards) through two games this season. 

6) Eagles (2-0) at Commanders (1-1) 1 p.m. ET | Fox | Spread: PHI -6.5 (47) Hurts' only 100-yard rushing game to date came in his first career start (against the Saints in 2020). This is an opportunity to do it again. -- Tim McManus

7) Lions (1-1) at Vikings (1-1) 1 p.m. ET | Fox | Spread: MIN -5.5 (53) Bold prediction: St. Brown will set a new NFL record with his ninth straight game with eight or more receptions. He was named the NFC Offensive Player of the Week on Wednesday, becoming Detroit's first receiver to win that honor since Calvin Johnson in 2015. 

7) Lions (1-1) at Vikings (1-1) 1 p.m. ET | Fox | Spread: MIN -5.5 (53) He's brimming with confidence after hitting career highs in receiving yards (116) and TDs (two) in the Week 2 win over Washington, and Detroit quarterback Jared Goff describes him as "a very friendly target" with his route running and fundamentals. He should again get a lot of attention in Minnesota. -- Eric Woodyard

8) Saints (1-1) at Panthers (0-2) 1 p.m. ET | Fox | Spread: NO -3 (41) Bold prediction: The Saints' pass rush will come alive for the first time this season, recording multiple sacks. New Orleans has only one sack this season, but Panthers quarterback Baker Mayfield has already been sacked six times through two games. 

8) Saints (1-1) at Panthers (0-2) 1 p.m. ET | Fox | Spread: NO -3 (41) Expect Saints defensive end Marcus Davenport to come up with a big game for the first time since amputating part of his pinkie in the offseason. -- Katherine Terrell

9) Texans (0-1-1) at Bears (1-1) 1 p.m. ET | CBS | Spread: CHI -2.5 (40) Bold prediction: The Texans will earn their first win of the year, and the stagnant offense (averaging 14.5 points) will finally wake up. Houston wants to run the ball with rookie running back Dameon Pierce so that Mills can play efficient football. 

9) Texans (0-1-1) at Bears (1-1) 1 p.m. ET | CBS | Spread: CHI -2.5 (40) The Bears' rushing defense is last in the NFL, allowing 189.5 yards on the ground, and that should be enough to spark the Texans' best offensive performance so far. -- DJ Bien-Aime

10) Jaguars (1-1) at Chargers (1-1) 4:05 p.m. ET | CBS | Spread: LAC -7 (47) Bold prediction: Los Angeles running back Austin Ekeler will gain nearly 200 all-purpose yards. In two previous games against Jacksonville, he has 332 yards and three touchdowns from scrimmage while averaged 12.9 yards per touch. 

10) Jaguars (1-1) at Chargers (1-1) 4:05 p.m. ET | CBS | Spread: LAC -7 (47) And with Herbert banged up, expect the Chargers to feature Ekeler heavily to keep the pass rush off their quarterback. -- Mike DiRocco

11) Packers (1-1) at Buccaneers (2-0) 4:25 p.m. ET | Fox | Spread: TB -1 (42) Bold prediction: The defenses will decide this game, not quarterbacks Aaron Rodgers and Tom Brady. Rodgers and Brady were 1-2 in Total QBR last season. This year? Brady is 23rd, and Rodgers is 25th. 

11) Packers (1-1) at Buccaneers (2-0) 4:25 p.m. ET | Fox | Spread: TB -1 (42) The Bucs won't have suspended receiver Mike Evans, and the Packers are still getting used to life without Davante Adams. 

11) Packers (1-1) at Buccaneers (2-0) 4:25 p.m. ET | Fox | Spread: TB -1 (42) Through two weeks, both teams' defenses rank in the top 10 in fewest points against and fewest yards allowed. -- Rob Demovsky

12) Rams (1-1) at Cardinals (1-1) 4:25 p.m. ET | Fox | Spread: LAR -3.5 (48.5) Bold prediction: Rams quarterback Matthew Stafford won't throw an interception. He has been intercepted five times in Los Angeles' first two games and has now thrown multiple interceptions in five straight regular-season games, which is the longest streak of his career. 

12) Rams (1-1) at Cardinals (1-1) 4:25 p.m. ET | Fox | Spread: LAR -3.5 (48.5) But Arizona has forced just two turnovers in its first two games, and neither was an interception. -- Sarah Barshop

13) Falcons (0-2) at Seahawks (1-1) 4:25 p.m. ET | Fox | Spread: EVEN (42) Bold prediction: Falcons running back Cordarrelle Patterson will gain over 100 scrimmage yards. Seattle is without safety Jamal Adams and gave up more than 100 all-purpose yards to Denver's Javonte Williams in Week 1 (108) and San Francisco's Jeff Wilson Jr. in Week 2 (103). 

13) Falcons (0-2) at Seahawks (1-1) 4:25 p.m. ET | Fox | Spread: EVEN (42) Patterson, who has more dual-threat capability than either Williams or Wilson, will make it three straight. -- Michael Rothstein

15) 49ers (1-1) at Broncos (1-1) 8:20 p.m. ET | NBC | Spread: SF -1.5 (45) Bold prediction: The 49ers will not allow Broncos QB Russell Wilson to throw a touchdown pass. That's no small thing, considering Wilson has tossed 37 career touchdowns against San Francisco, the most of his career against a team, and his teams are 17-4 against the Niners. 

15) 49ers (1-1) at Broncos (1-1) 8:20 p.m. ET | NBC | Spread: SF -1.5 (45) But this 49ers defense has been stingy in the first two weeks, allowing just 142.5 passing yards per game and just 210 total yards per game, the best marks in the NFL. Plus, Wilson has just two TD passes this season, his fewest through two games since 2017. -- Nick Wagoner

16) Cowboys (1-1) at Giants (2-0) Monday, 8:15 p.m. ET | ESPN/ABC | Spread: NYG -1 (39) Bold prediction: Dallas running back Ezekiel Elliott will have more rushing yards than the Giants' Saquon Barkley. Barkley currently leads the NFL in rushing with 236 yards, while Elliott has 105 yards on 25 carries in two games. 

16) Cowboys (1-1) at Giants (2-0) Monday, 8:15 p.m. ET | ESPN/ABC | Spread: NYG -1 (39) But Elliott likes seeing the Giants more than Barkley likes seeing the Cowboys. Elliott has four 100-yard games (and a 90-yarder) against the Giants in 10 tries. Barkley, meanwhile, has two 100-yard efforts versus Dallas in six contests, but he has not topped 28 yards three times. -- Todd Archer

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