By now, you've probably heard at least a dozen times that Kansas City Chiefs quarterback Patrick Mahomes is an underdog at home for the first time in 41 starts.
Yet despite his 7-0-1 record against the spread, several sportsbooks kept moving the line in favor of the Buffalo Bills on the road, as sharp money poured in to back them.
Sometimes betting trends help highlight unique angles and advantages within a game. Other times, they end up being moot.
Last week, the Pittsburgh Steelers were the largest underdogs in franchise history since the AFL/NFL merger following their blown lead and straight up loss to the New York Jets at home.
They had lost three straight and hadn't lost four in a row since 2016. Via Evan Abrams, teams that lost to the Jets over the last 11 games went on to go 2-9 ATS the following week.
Sure enough, the Steelers couldn't cover a 14-point spread on the road vs. the Bills, getting demolished 38-3.
What are the most notable betting trends to help you get a leg up in your wagers for Week 6 in the NFL?
Here's a look at the latest betting odds, spreads and totals for every game on the board this week, along with several unique betting trends for every team and each matchup:
THURSDAY, OCTOBER 13 - THURSDAY NIGHT FOOTBALL Washington Commanders vs. Chicago Bears Betting Trends and Odds Commanders: Washington is 0-4 SU and ATS since Week 1 The Commanders are 5-8-1 as road underdogs since 2020 Bears: 1) Chicago is 3-0-1 ATS as a home favorite since the start of 2021 2) The Bears are 2-3 ATS this season
SUNDAY, OCTOBER 16 - EARLY SLATE San Francisco 49ers vs. Atlanta Falcons Betting Trends and Odds 49ers: 1) San Francisco has covered in each of its wins this season 2)The 49ers are 5-1 ATS in their last six games as at least a 6-point favorite Falcons: 1) The Falcons are 5-0 ATS this season 2) Atlanta has hit the UNDER in its last two games
SUNDAY, OCTOBER 16 - EARLY SLATE New England Patriots vs. Cleveland Browns Betting Trends and Odds Patriots: 1) The OVER is 4-1 in Browns games this season 2) Cleveland is 6-11 ATS as a home favorite since the start of 2020 Browns: 1) The Patriots have covered in their last two games 2) New England is 5-6 ATS as a road underdog since 2020
SUNDAY, OCTOBER 16 - EARLY SLATE New York Jets vs. Green Bay Packers Betting Trends and Odds Jets: 1) New York has covered and hit the OVER in each of its wins 2) The Jets are 2-0 ATS as road underdogs this season Packers: 1) The OVER has hit in the Packers’ last two games 2) The Packers are 1-2 ATS in non-divisional games this season
SUNDAY, OCTOBER 16 - EARLY SLATE Jacksonville Jaguars vs. Indianapolis Colts Betting Trends and Odds Jaguars: 1) Jaguars are 5-0 to the OVER in their last five road games 2) Jacksonville 5-1 ATS in last six meetings vs. Indianapolis 3) Underdog is 6-0 ATS in last six head-to-head matchups Colts: 1) Colts 5-2 ATS in last seven October games 2) Under is 4-0 in Colts last four home games
SUNDAY, OCTOBER 16 - EARLY SLATE Minnesota Vikings vs. Miami Dolphins Betting Trends and Odds Vikings: 1) Vikings are 1-4 ATS in their last five games. 2) The OVER is 10-3 in the Viking's last 13 games. 3) Vikings are 1-5 ATS in their last six road games. Dolphins: 1) Dolphins are 10-4 TS in their last 14 games. 2) Dolphins are 8-0 straight up in their last eight home games. 3) Dolphins are 6-2 ATS in their last eight games against NFC opponents.
SUNDAY, OCTOBER 16 - EARLY SLATE Cincinnati Bengals vs. New Orleans Saints Betting Trends and Odds Bengals: 1) Bengals are 11-2 ATS in their last 13 games. 2) The UNDER is 10-0 in the Bengals' last 10 games. 3) Bengals are 5-1 ATS in last six games vs. Saints Saints: 1) The UNDER is 8-4 in the Saints' last 12 games. 2) Saints are 4-11 ATS in last 15 games vs. AFC North opponents.
SUNDAY, OCTOBER 16 - EARLY SLATE Baltimore Ravens vs. New York Giants Betting Trends and Odds Ravens: 1) The UNDER is 3-2 in Ravens games this year 2) Since 2019, the Ravens are 12-7-1 ATS as a road favorite Giants: 1) New York is 4-1 ATS this season 2) The Giants are 8-18 ATS as a home underdog in the last five years
SUNDAY, OCTOBER 16 - EARLY SLATE Tampa Bay Buccaneers vs. Pittsburgh Steelers Betting Trends and Odds Buccaneers: Trends 1) Buccaneers are 2-4 ATS in their last six games 2) The UNDER is 4-1 in Buccaneers games this season 3) Buccaneers are 1-5 ATS in last six games against Steelers 4) Buccaneers are 1-6 ATS in their last seven games played in Week 6. Steelers: 1) Steelers are 1-4-1 ATS in their last six games. 2) Steelers are 0-7 ATS in their last seven games against NFC opponents.
UNDAY, OCTOBER 16 - LATE AFTERNOON SLATE Carolina Panthers at Los Angeles Rams Betting Trends and Odds Panthers: 1) Panthers are 1-11 ATS in their last 12 games. 2) Panthers are 8-3-1 ATS in their last 12 games against Rams. 3) Panthers are 0-5 ATS in their last five road games. Rams: 1) Rams are 1-6 ATS in their last seven games. 2) The UNDER is 6-1 in the Rams' last seven games. 3) Rams are 1-5 ATS in their last six home games.
UNDAY, OCTOBER 16 - LATE AFTERNOON SLATE Arizona Cardinals at Seattle Seahawks Betting Trends and Odds Cardinals 1) Cardinals are 16-5-1 ATS in their last 22 October games 2) Cardinals have hit four straight unders, and 4-0 in unders vs. NFC Seahawks: 1) Seahawks 4-1 ATS in last five October matchups 2) Over is 4-1 in last five Seattle home games 3) Underdog is 11-2-1 ATS in their last 14 meetings (via Covers)
UNDAY, OCTOBER 16 - LATE AFTERNOON SLATE Buffalo Bills at Kansas City Chiefs Betting Trends and Odds Bills: 1) The UNDER is 4-1 in Bills games this season 2) The UNDER is 3-0 in Bills road games this season 3) Bills are 7-2-2 ATS in last 11 games Chiefs: 1) Patrick Mahomes 7-0-1 ATS as an underdog in his career 2) Chiefs are 6-2 ATS in last eight games against Bills 3) The OVER is 3-0 in last three meetings between teams
SUNDAY, OCTOBER 16 - SUNDAY NIGHT FOOTBALL Dallas Cowboys vs. Philadelphia Eagles Betting Trends and Odds Cowboys: 1) Dallas is 10-1 ATS in last 11 road games 2) Cooper Rush is 4-0 SU and ATS as Cowboys' starting QB in 2022 3) Under is 10-1-1 in Dallas' last 12 games following a ATS AND SU win Eagles: 1) Philly is 4-1-1 ATS in their last six home games 2) Eagles are 2-5 ATS in their last seven matchups vs. the NFC East 3) Over has gone 6-1 in Philly's last seven home games
MONDAY, OCTOBER 17 - MONDAY NIGHT FOOTBALL Denver Broncos vs. Los Angeles Chargers Betting Trends and Odds Broncos: 1) The Broncos are 1-4 ATS this season 2) The UNDER is 4-1 in the Broncos’ five games this season Chargers: 1) The Chargers are 4-1 ATS this season 2) The OVER is 3-2 in the Chargers’ five games this season